In Vivo Pharmacodynamic Evaluation of B-p53 KO Mice (CAT#: STEM-AE-0660-LGZ)

Introduction

The p53 gene is the gene that has the highest correlation with human tumors. p53 is a tumor suppressor gene, known as the "guardian of the genome", which can regulate cell cycle and participate in DNA damage repair. When cells are damaged beyond repair, p53 can induce cell apoptosis and prevent the occurrence of cancer. Studies have shown that about half of all human tumors are caused by mutations in the p53 gene. When p53 is knocked out or mutated, it can lead to the occurrence of spontaneous tumor in mice, which is one of the better models for the study of human tumor diseases.