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In Vivo Pharmacodynamic Evaluation of Bile Duct Ligation Induced Liver Fibrosis (CAT#: STEM-AE-0667-LGZ)

Introduction

Metabolic diseases are diseases caused by the accumulation or deficiency of certain metabolic substances such as sugars, fats, proteins (amino acids), purines, pyrimidines, and copper when biochemical processes in the body are disrupted. Symptoms vary in severity and diagnosis depends on clinical manifestations and blood, urine and other biochemical tests. There is no effective cure, the main is to eliminate the cause and symptomatic treatment. The prognosis depends on the etiology, severity of symptoms and treatment effect.




Principle

Bile duct ligation causes extrahepatic biliary obstruction, which leads to bile duct dilatation and bile stasis. When the pressure in the bile duct increases further, the intrahepatic bile ducts dilate and rupture, the intrahepatic blood vessels are compressed by both the dilated bile ducts and the extravasated bile, the hepatocytes become ischaemic and necrotic, and fibrous tissue proliferates, surrounding the liver lobules and spreading around the hepatocytes, which can eventually lead to cirrhosis.

Applications

Metabolic Disease

Procedure

1. Disease model construction.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.

Materials

• Sample Type: liquid or powder
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