In Vivo Pharmacodynamic Evaluation of Experimental Autoimmune Encephalomyelitis (EAE) Mouse Disease Model (CAT#: STEM-AE-0679-LGZ)

In rodents such as mice and rats, models of EAE can be induced immunologically using spinal cord homogenates, purified myelin sheath, myelin proteins (such as myelin basic protein MBP, protein lipoprotein PLP, and myelin oligodendrocyte glycoprotein MOG), or peptides of these proteins. This is likely due to myelin specific T cells being activated peripherically, crossing the blood-brain barrier into the central nervous system and being reactivated, triggering a cascade of inflammatory responses leading to demyelination and axonal cell apoptosis, ultimately leading to nerve damage and loss of function. Clinical symptoms were evaluated using a standardized scoring system to measure the degree of disease induction. Local demyelination and inflammatory leukocyte infiltration were seen in stained sections of pathological tissue.

Autoimmune Disease

1. Disease model construction.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.

• Sample Type: liquid or powder