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In Vivo Pharmacodynamic Evaluation of HCT8 Cell Line Based Colon Cancer (CAT#: STEM-AE-0033-LGZ)

Introduction

Colon cancer is a common malignant tumor of digestive tract occurring in the colon. The incidence of gastrointestinal tumors ranked third. Colon cancer is mainly adenocarcinoma, mucinous adenocarcinoma and undifferentiated carcinoma. The gross shape is polyp, ulcerate type, etc. Colon cancer can develop circumferentially along the intestinal wall, spread up and down along the longitudinal diameter of the intestinal canal or infiltrate deep into the intestinal wall. In addition to lymphatic, blood flow metastasis and local invasion, it can also spread to the abdominal cavity or along the suture and incision surface. Patients with chronic colitis, colon polyp and male obesity are susceptible groups.




Principle

In vivo activity is the gold standard for the evaluation of drug biological activity, and it is the first verification of non-human comprehensive activity. In vivo pharmacodynamic evaluation plays a decisive role in the confirmation of candidate molecules and the screening of clinical target indications, and is an indispensable link in the development of new drugs. We provide a variety of disease animal models including inflammation, immunity, metabolism, etc., to meet the needs of different new drug research and development projects of customers, and accept customized services.
In vivo pharmacodynamic evaluation, as the basic research of new drugs, is carried out on animals. It is to verify the effect of drugs with the comprehensive participation of a number of other factors, and to understand the effect of drugs on a certain part of the body by comparing and analyzing the animal signs, in vitro organs, blood components, histone expression and tissue changes before and after drug administration.

Applications

Colon Cancer

Procedure

1. Disease model construction.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.

Materials

• Sample Type: liquid or powder

Notes

Oncology efficacy Service package:
In vivo syngeneic model
In vivo CDX model
In vivo PBMC humanized model
In vivo transgenic mouse model
In vivo orthotropic or Metastasis tumor model
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