In Vivo Pharmacodynamic Evaluation of TNBS Induced IBD Mouse Disease Model (CAT#: STEM-AE-0676-LGZ)

Introduction

Inflammatory Bowel Disease (IBD) is a non-specific chronic inflammatory disease of the colon or gastrointestinal tract, including ulcerative colitis (UC) and Crohn's disease (CD), Clinical symptoms of IBD include recurrent diarrhea, abdominal pain, intestinal bleeding/blood in the stool, fever, and weight loss. The pathogenesis of IBD is still unclear. Studies have shown that susceptibility genes, immune system, external environment and intestinal microorganisms are all related to the disease. A variety of preclinical mouse models have been used to study IBD, and disease models based on different induction methods have specific uses. Mouse enteritis induced by Dextran Sulfate Sodium Salt (DSS) is the most widely used chemical induced mouse IBD model. By dissolving DSS in drinking water to induce acute ulcerative enteritis or chronic colitis, the intestinal epithelial cells of mice are destroyed, non-specific immune cells release cytokines, and eventually the integrity of the mucosal barrier is damaged. The animals show significant weight loss, loose stool, blood in the stool, and granulocytes. The clinical symptoms and pathological features are very similar to those of human ulcerative colitis.