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The diffusion of macromolecules through polymer solutions and gels is important in many industrial and biological applications. For example, a better understanding of how macromolecular drugs are transferred in living tissue is essential for the design of macromolecule-based therapies. The transport of macromolecules across membranes, in porous chromatography supports, and in porous media is important to bioseparations. In the food and oil industries, enzymes are often used to degrade polysaccharide chains at very high polymer concentrations. The reactions are diffusioncontrolled, and an understanding of the diffusion limitations is necessary to predict process performance.