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Nanoparticles hold great promise for the delivery of therapeutics. One emerging class of these materials are nanolipoprotein particles (NLPs), which are mimetics of naturally occurring high-density lipoproteins (HDLs). NLPs are attractive for drug or vaccine formulation since they: (1) can be loaded with hydrophobic “cargo” molecules, (2) have high water solubility and (3) are easily modified for targeted delivery to specific tissues.