NMCHT Type I Chromatographic Media, 100 g (CAT#: STEM-C-3850-ZJF)

Ceramic hydroxyapatite (CHT) is a hydroxyapatite-based composite material with significant value as a chromatographic medium. It features a spherical structure with macropores and functions as a mixed-mode resin, combining metal affinity and cation exchange capabilities. This unique combination provides highly selective and efficient purification solutions. CHT media is well-suited for purifying a wide range of biomacromolecules, including antibodies, viral particles, vaccines, recombinant proteins, and nucleic acids.
CHT is available in two distinct types to accommodate different purification needs. Type I offers higher binding capacity, making it ideal for the purification of small proteins. Type II features a larger pore size, specifically designed for the efficient purification of larger macromolecules such as viruses, IgM, virus-like particles (VLPs), and plasmids. These tailored options ensure reliable performance across diverse bioprocessing applications.

Functional group: Ca²⁺, PO₄³⁻, -OH
Particle size: 40±4 μm
Tap-settled density: 0.72 g/mL
DBC (IgG): ~35 mg/mL
Recommended flow rate: 50-1000 cm/h
Sanitization: 1-2 M NaOH
pH stability: 6.5-14, at least 1 year in 1 M NaOH
Regeneration: 0.4 M sodium phosphate buffer, pH 7-7.5; 1 M trisodium phosphate, pH 11-12; 0.4-1 M potassium phosphate buffer
Autoclavability: 121 ℃, 20 min, phosphate buffer, pH 7
Storage: 0.1 M NaOH, room temperature

Mixed-Mode Chromatography Media: Ceramic Hydroxyapatite (CHT) offers both metal affinity and cation ion exchange capabilities for unique selectivity.
Versatile Purification: Suitable for the purification of a wide range of biomacromolecules, including antibodies, virus particles, vaccines, recombinant proteins, and nucleic acids.
Spherical Appearance with Macropores: The spherical shape and macropores of CHT provide excellent flow properties and efficient separation.
NMCHT Type I: Higher binding capacity, ideal for small protein purification.
NMCHT Type II: Larger pore size, optimized for the purification of macromolecules such as viruses, IgM, VLP particles, and plasmids.
Effective Purification Solutions: Offers unique and effective purification solutions with high selectivity, suitable for diverse biopharmaceutical applications.

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