Rapid separation of isomeric perfluoroalkyl substances by high-resolution differential ion mobility mass spectrometry (CAT#: STEM-ST-0166-LJX)

Introduction

Perfluorinated alkyl substances (PFASs) are a class of persistent organic compounds that are widely used in many consumer products and industrial applications, including fire-fighting foams, fire-retardant coatings for fabrics, non-stick surface coatings, and food packaging. PFASs can bioaccumulate and adversely affect the health of marine organisms and potentially humans. Liquid chromatography-mass spectrometry (LC-MS) is the most widely used approach for isomeric PFAS analysis and GC-MS has also been used.

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Principle Applications Procedure Materials Notes Related Products

Principle

Ion mobility spectrometry–mass spectrometry (IMS-MS) is an analytical chemistry method that separates gas phase ions based on their interaction with a collision gas and their masses. In the first step, the ions are separated according to their mobility through a buffer gas on a millisecond timescale using an ion mobility spectrometer. The separated ions are then introduced into a mass analyzer in a second step where their mass-to-charge ratios can be determined on a microsecond timescale.

Applications

For studying the gas phase ion structure
For detecting the chemical warfare agents and explosives
For the analysis of proteins, peptides, drug-like molecules and nano particles
For monitoring isomeric reaction intermediates and probe their kinetics
For proteomics and pharmaceutical analysis

Procedure

1. Add sample
2. The ions in the sample are separated in the ion mobility spectrometer
3. The separated ions are introduced into the mass analyzer for detection
4. Store the detection results

Materials

• Sample Type:
Perfluorinated alkyl substances

Notes

1. Ion mobility spectrometry is also a very fast technique, making it suitable for high-throughput applications. The entire analysis can be completed in just a few minutes.
2. The method is extremely sensitive and able to detect trace amounts of contaminants that other spectrometry methods would miss.
3. The effective separation of analytes achieved with this method makes it widely applicable in the analysis of complex samples such as in proteomics and metabolomics.

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