Recombinant Human CD138 Protein, Seafrom (CAT#: STEM-CT-0148-ZJF)

The Recombinant Human CD138 Protein manufactured by Seafrom is suitable for plasma cell differentiation and function.
Syndecan-1 (SYND1 or SDC1) is a transmembrane heparan sulfate proteoglycan that belongs to the syndecan family. It serves various functions in mediating cell binding, signaling, and cytoskeletal organization. Syndecan receptors are involved in internalizing the HIV-1 tat protein. Syndecan-1 is essential for cell proliferation, migration, and interactions with the extracellular matrix through its receptor for matrix proteins.
As a marker, Syndecan-1 is particularly useful for identifying plasma cells. It is important to note that the use of Syndecan-1 as a marker is most effective when testing cells that are already known to be derived from blood.
The freeze-dried (lyophilized) form of the protein can be stored at 4℃ for up to 24 months. Once reconstituted, the liquid can be stored at -20℃ for 6-12 months, with precautions taken to avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Source: Human
Synonyms: SDC1, Syndecan-1, SYND1, SDC
Protein Sequence: The DNA sequence encodes human CD138 (UniProtKB/Swiss-Prot: P18827.3), expressed with Fc tag at the C-terminus.
Molecular Weight: Recombinant human CD138 protein contains 463 amino acids, with a predicted theoretical molecular weight of 50.8 kD.
Purity: ≥95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg
Biological Activity: Enhanced Saos2 (human osteosarcoma cells) adhesion to human fibronectin was detected by fixing the protein. The ED50 for this effect is 5-10 μg/mL, using 5x10^4 cells/well, and human Syndecan-1 and human fibronectin (0.5 μg/ml) as coated plates.
Purification Method: Chromatographic purification
Composition: Sterile PBS (pH 7.4) freeze-dried powder containing 6% mannitol.

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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