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Rhinosinusitis (rhinosinusitis) is one of the common and frequently-occurring diseases in clinical otolaryngology. Severe patients will cause their sense of smell disturbance and affect the quality of human life. The pathogenic bacteria of sinusitis are mainly aerobic and anaerobic bacteria such as Streptococcus pneumoniae (40%), Staphylococcus, Haemophilus influenzae. At present, various animal models of rhinosinusitis such as rabbits, rats and mice have been explored and established in related fields, and in-depth research on rhinosinusitis has been carried out using these models.