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Spindlin1 is a methyl-lysine unwinding protein that can have trimethylated lysine in histone H3 through only the second high affinity recognition site 4 (H3K4me3) of the three Tudor-like structural domains. spindlin1 is also an overexpressed gene fragment found in human spindlin1 in ovarian cancer cells as a potential target for drug development. In addition, spindlin1 is highly expressed in various types of malignant tissues, including non-small cell lung cancer, ovarian tumours and some hepatocellular carcinomas. abnormal expression of spindlin1 results in delayed mid-cell cycle and leads to chromosomal instability. Reducing Spindlin1 protein levels strongly impairs the proliferation of liposarcoma cells and increases apoptosis. As the Spindlin1 example shows, methyl-lysine readers have great potential as targets for drug development.