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Virus-like-particles (VLPs) are self-assembled, proteinaceous nanoparticles derived from naturally occurring viruses. In last years, VLPs attracted broad scientific interest due to their properties as versatile scaffold in nanotechnology. These beneficial characteristics are mainly originated from their particle integrity. Since VLPs are not infectious and do not replicate, they are considered as a safe format in biomedicine. Virus-like-particles per se are robust structures, and are highly immunogenic as the extremely repetitive and dense presentation of epitopes on the VLP surface efficiently stimulates B cells. The majorities of these alterations implicate disadvantages in vaccine development as they directly affect the foreign epitope sequence and may negatively change the epitope conformation.