Analysis of ABCC1 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-2471-LGZ)

Introduction

Official Full Name: ATP binding cassette subfamily C member 1
Also known as: MRP; ABCC; GS-X; MRP1; ABC29; DFNA77
The protein encoded by this gene is a member of the ATP-binding cassette transporter superfamily. ABC proteins transport various molecules outside and inside the cell membrane. The ABC genes are grouped into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily and is involved in multidrug resistance. The protein acts as a multispecific organic anion transporter with oxidized glutamate, cysteine leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronate and sulfate conjugates of steroid hormones and bile salts. Alternative splicing variants of this gene have been described, but the full-length nature is unknown.