Analysis of ABL2 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0748-LGZ)

Introduction

Official Full Name: ABL proto-oncogene 2, non-receptor tyrosine kinase<br />Also known as: ARG; ABLL<br />This gene encodes a member of the Abelson family of non-receptor tyrosine protein kinases. This protein is highly similar to c-abl oncogene 1 protein, including tyrosine kinase, SH2 and SH3 domains, and plays a role in cytoskeleton rearrangement through its C-terminal F-actin and microtubule-binding sequences. This gene is expressed in both normal cells and tumor cells, and is involved in the translocation of ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants of this gene have been found to encode different protein isoforms.