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A Disintegrin And Metalloproteinases(ADAMs) family is a class of zinc ion-dependent transmembrane glycoprotein hydrolases containing several domains, such as propeptide domain, metalloproteinase domain, deintegrin domain, cysteine-rich domain, and epithelial growth factor-like domain near the membrane. They are involved in a variety of biological processes, including proteolysis, signal transduction, cell adhesion, migration, etc., and are closely related to the occurrence and invasion of tumors.