Analysis of Angiotensinogen/AGT/SerpinA8 by ELISA (CAT#: STEM-MB-1575-LGZ)

Introduction

Angiotensinogen (AGT), also known as SerpinA8, is a member of the serine protease inhibitor family. AGT is an alpha-2-globulin that is constitutionally produced by the liver and released into the bloodstream. AGT is an essential component of renin-angiotensin system and an effective blood pressure regulator. AGT can be cleaved into three chains: angiotensin-1, angiotensin-2, and angiotensin-3. Absence of AGT is associated with essential hypertension and tubular hypoplasia. Several serine protease inhibitors (antithrombin, maspin, pigment epithelium-derived factors, and kallistatin) have recently been shown to have anti-angiogenic activity, indicating a common mechanism for endothelial cell proliferation and migration. AGT and its renin cleavage products are also angiogenic inhibitors in the range of plasma concentrations observable in vitro and in vivo.