Analysis of Apolipoprotein AII/Apo A2 by ELISA (CAT#: STEM-MB-1565-LGZ)

Introduction

Apolipoprotein AII (Apo A2) is the second largest APolipoprotein in human plasma high density lipoprotein (HDL) after Apo A1, and is the most hydrophilic among exchangeable APolipoproteins. Apo A2 is synthesized by the liver and small intestine and exists in plasma as a monomer or dimer. The Apo A2 gene consists of four exons and three introns. Four exons encode the 5' -terminal untranslated region, propeptide, a short n-terminal domain, and a C-terminal domain composed of a variable number of lipid binding androgynous helices. Apo A2 can stabilize HDL structure and affect HDL metabolism by binding lipids. The role of Apo A2 in lipid metabolism and atherosclerosis shows important clinical significance. Apo A2 levels are associated with increased atherosclerotic susceptibility, free fatty acid levels, body fat, and insulin resistance.