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Apolipoprotein M (Apo M) is encoded by the APOM gene in humans. The protein encoded by the gene is an apolipoprotein, a member of the Apolipoprotein family. Apo M was found to be associated with high density lipoproteins, and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. Apo M is secreted through the plasma membrane, but still binds to the membrane and participates in lipid transport. It was found that the APOM gene has two transcribed variants encoding two different isomers, but only one of them has been fully identified. The average molecular weight of Apo M was 21253 Da and that of the single isotope was 21239 Da.