Analysis of ARF1 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0256-LGZ)

Introduction

Official Full Name: ADP ribosylation factor 1
Also known as: PVNH8
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. Members of this family encode small guanine nucleotide-binding proteins that stimulate cholera toxin ADP-ribosyltransferase activity and function as activators of phospholipase D in vesicle trafficking. The gene product includes 6 ARF proteins and 11 ARF-like proteins, constituting a family of the RAS superfamily. ARF proteins are classified into class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), with members of each class sharing a common genetic organization. The ARF1 protein localizes to the Golgi apparatus and plays a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants of this gene encoding the same protein have been found.