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Official Full Name: asporin
Also known as: OS3; PLAP1; PLAP-1; SLRR1C
This gene encodes a cartilage extracellular protein, a member of the leucine-rich small proteoglycan family. The encoded protein may regulate cartilage formation by inhibiting transforming growth factor-β1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartate repeat region of this gene are associated with susceptibility to osteoarthritis and intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.