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Official Full Name: activating transcription factor 6
Also known as: ACHM7; ATF6A
This gene encodes a transcription factor that activates target genes of the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein embedded in the endoplasmic reticulum. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor in quiescent rather than proliferating squamous carcinoma cells. There are conflicting reports on the association of polymorphisms of this gene with diabetes in different populations, but another polymorphism is associated with elevated plasma cholesterol levels. This gene is also considered a potential therapeutic target for cystic fibrosis.