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Official Full Name: ATPase Na+/K+ transporting subunit alpha 4
Also known as: ATP1A1; ATP1AL2
The protein encoded by this gene belongs to the p-type cation transporting ATPase family and belongs to the Na+/K+ - ATPase subfamily. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradient of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, sodium-coupled transport of various organic and inorganic molecules, and electrical excitability in nerves and muscles. The enzyme is composed of two subunits, a larger catalytic subunit (α) and a smaller glycoprotein subunit (β). The catalytic subunit of Na+/K+ -atpase is encoded by multiple genes. This gene encodes an α4 subunit. Alternative splicing transcript variants encoding different isoforms have been identified.