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BIM gene (also known as BCL2L11 gene) encoded products belong to the BCL-2 protein family members, is one of the most active pro-apoptotic proteins. Bcl-2 family members can form homologous or heterodimers involved in regulating and promoting apoptosis, all containing bcl-2 homologous domain 3 (BH3). Some members of BCL-2, BCL-XL and MCL1 are anti-apoptotic, while others are pro-apoptotic.