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Recombinant Human Bone Morphogenetic Protein 4 (BMP-4) is a bone morphogenic protein that constitutes a subfamily of the TGF-β superfamily of structurally related signaling proteins. BMP-4 is also involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with many skeletal disorders, including hereditary dysplastic ossification disorders.