Analysis of BMP-9/GDF2 by ELISA (CAT#: STEM-MB-1541-LGZ)

Introduction

Human bone morphogenetic protein 9 (BMP-9), also known as growth differentiation factor 2 (GDF-2), is a member of the BMP subgroup of transforming growth factor β superfamily proteins, signaling through heterodimer complexes composed of type Ⅰ and type Ⅱ BMP receptors. BMP-9 regulates the development and function of a variety of embryonic and adult tissues. BMP-9 is synthesized and secreted by non-parenchymal cells of the liver. It can promote lipid metabolism and inhibit glucose production. BMP-9 plays an important role in the development and maintenance of cholinergic neuronal phenotypes in the embryonic central nervous system. BMP-9 also induces mesenchymal stem cells to differentiate into chondrogenic cell lines. At low concentrations, BMP-9 is a proliferative factor of hematopoietic progenitor cells. But at high concentrations, it promotes the production of TGF-β1 and inhibits the formation of colonies of hematopoietic progenitor cells.