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Official Full Name: calcium voltage-gated channel subunit alpha1 E
Also known as: BII; CACH6; DEE69; gm139; Cav2.3; EIEE69; CACNL1A6
Voltage-dependent calcium channels are multisubunit complexes composed of α-1, α-2, β, and δ subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells and are involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes the α-1e subunit of the R-type calcium channel, which belongs to the "high voltage activated" group and may be involved in the regulation of neuronal firing patterns important for information processing. Alternative splice transcript variants encoding different isoforms have been described for this gene.