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Official Full Name: calpain 10<br />Also known as: CANP10; NIDDM1<br />Calpains are a ubiquitous and well conserved family of calcium-dependent cysteine proteases. The calpain protein is a heterodimer composed of an invariant small subunit and a variable large subunit. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; -binding domain. This gene encodes a large subunit. It is an atypical calpain because it lacks a calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is organizationally similar to calpain5 and calpain6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and is located in the NIDDM1 region. Multiple alternative transcript variants of this gene have been described.