Analysis of CD5L (Human) by ELISA (CAT#: STEM-MB-0732-LGZ)

Introduction

CD5L antigen-like protein (CD5L) as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues, regulates the mechanisms of inflammatory responses, such as infection or arteriosclerosis. It inhibits the size of lipid droplets in fat cells. After entering mature adipocytes through CD36-mediated endocytosis, it binds to the cell membrane FASN, inhibits the activity of fatty acid synthase, leads to lipolysis, and degrades triacylglycerol into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs as obesity progresses: after inflammatory macrophages are recruited to adipose tissue, they are involved in obesity-associated inflammation, which is responsible for insulin resistance and obesity-associated metabolic disease. Intracellular lipid regulation mediated by CD5L has a direct effect on transcriptional regulation mediated by the nuclear receptor ROR-gamma (RORC).