Analysis of COPA Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0885-LGZ)

Introduction

Official Full Name: COPI coat complex subunit alpha<br />Also known as: AILJK; HEP-COP; alpha-COP<br />In eukaryotic cells, protein transport between the ER and the Golgi compartment is mediated in part by nonclathrin-coated vesicle coat proteins. Seven coat proteins have been identified that represent subunits of a complex known as coat. Subunits were designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP and zeta-COP. COPA-encoded α-COP shares high sequence similarity with the α-subunit RET1P of the coat complex in yeast. In addition, the N-terminal 25 amino acids of α-COP encode a bioactive peptide, xenin, which stimulates the exocrine pancreas and may act as a gastrointestinal hormone. Alternative splicing results in multiple spliced forms encoding different isoforms.