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COX2 is a key enzyme in the process of prostaglandin biosynthesis. It acts as a dioxygenase and a peroxidase, mediates the formation of prostaglandins from arachidonic acid, and plays a special role in the inflammatory response process. By inhibiting COX2 to rapidly reduce inflammatory, pain and febrile responses, long-term use of these drugs reduces fatal blood clot events, as well as the development of colon cancer and Alzheimer's disease.