Analysis of CXCL3/GRO-γ by ELISA (CAT#: STEM-MB-1562-LGZ)

Introduction

CXCL1, CXCL2, and CXCL3, known as GRO alpha, GRO beta (MIP-2 alpha), and GRO gamma (MIP-2 beta), respectively, are members of the CXC subfamily of chemokines. The mature CXCL1/2/3 protein is highly affinitively bound to IL-8 receptor type B and is an effective neutrophil attractor and activator. Chemokines mainly act on leukocytes and regulate their transport. In general, members of the chemokine α family preferentially chemotactic and activate neutrophils. Recombinant Human Growth Regulatory Oncogene γ(GRO-γ) is a 7.9kDa protein composed of 73 amino acids, including the "ELR" modle shared by the CXC chemokine family that binds to CXCR1 or CXCR2. The amino acid sequence homology of mature human CXCL3 (aa 35-107) and mouse CXCL3 and rat CXCl3 was 70% and 74%, respectively. CXCL3 plays a key role in monocyte migration and adhesion through its interaction with the CXCR2 receptor.