Analysis of DAP3 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0899-LGZ)

Introduction

Official Full Name: death associated protein 3<br />Also known as: DAP-3; S29mt; MRPS29; MRP-S29; bMRP-10<br />Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and assist in protein synthesis within mitochondria. Mitochondrial ribosomes consist of a small 28S subunit and a large 39S subunit. They are estimated to be composed of 75% protein and rRNA compared to prokaryotic ribosomes, whose proportions are reversed. Another difference between mammalian ribosomes and prokaryotic ribosomes is that the latter contain 5S rRNA. The proteins that make up the mitochondrial body vary widely in sequence and sometimes in biochemical properties across species, making sequence homology difficult to identify. This gene encodes the 28S subunit protein, which is also involved in the apoptotic pathway triggered by tumor necrosis factor-alpha, Fas ligand, and interferon-gamma. This protein may bind ATP/GTP and may be a functional partner of mitochondrial protein S27. Multiple alternatively spliced transcript variants encoding different isoforms of this gene have been found. Pseudogenes corresponding to this gene are located on chromosomes 1q and 2q.