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Delta-like protein 1 (Dlk1, DLL1) is a transmembrane protein characterized by epidermal growth factor (EGF)-like repeats. DLL1 is also known as preadipocyte factor 1 (pref-1) because of its ability to inhibit preadipocyte differentiation, which regulates the differentiation of several other cell types. It is a ligand for the Notch receptor.