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Factor VII (proconvertin) is one of the proteins in the coagulation cascade that causes blood to coagulate. It is an enzyme of the serine protease class. Once bound to tissue factor released from damaged tissue, it is converted to factor VIIa (or factor VIIa, activated factor VII), which in turn activates factors IX and X. The action of this factor is blocked by tissue factor pathway inhibitor (TFPI), which is released almost immediately after blood clotting begins.