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DKK (Dickkopf) is a group of secreted glycoproteins, including DKK-1-4 four members. DKKs have a signal sequence and two cysteine-rich conserved domains, namely CYS1 near the N-terminus and CYS2 near the C-terminus. Human DKK-1 is composed of 266 amino acids, and its relative molecular mass is about 29k. DKK-1 is an inhibitory molecule of Wnt pathway.