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CXCL5, also known as neutrophil-activating peptide 78 (ENA-78), is a CXC chemokine containing an ELR motif. CXCL5 promotes angiogenesis by interacting with its specific receptor CXCR2. CXCL5 is expressed by many immune cells such as macrophages, eosinophils, and non-immune cells including mesothelial cells and fibroblasts. The CXCL5/CXCR2 axis not only contributes to neutrophil recruitment but also regulates neutrophil function in melanoma.