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Also known as: FVL; PCCF; THPH2; RPRGL1<br />This gene encodes an important cofactor of the coagulation cascade. The factor circulates in the plasma and is converted to the active form by the thrombin-releasing activating peptide during coagulation. This creates heavy and light chains linked together by calcium ions. Activin is a cofactor involved in the activation of coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in autosomal recessive hemorrhagic or autosomal dominant thrombosis, ie, activated protein C resistance.