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Official Full Name: flavin containing dimethylaniline monoxygenase 4
Also known as: FMO2
Metabolic n-oxidation of dietary aminotrimethylamine (TMA) is mediated by flavin-containing monooxygenases and influenced by inherited FMO3 polymorphisms in humans. This results in decreased TMA n oxidation capacity in a small proportion of the population and leads to fish odor syndrome (trimethylaminuria). The three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are Nadph-dependent diaphorases that catalyze the oxidation of nucleophilic soft heteroatom centers in drugs, pesticides, and xenobiotics.