Analysis of H3C15 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1055-LGZ)

Introduction

Official Full Name: H3 clustered histone 15<br />Also known as: H3/n; H3/o; H3C13; H3C14; HIST2H3A<br />Histones are fundamental nuclear proteins responsible for the structure of eukaryotic chromosome fibers in the nucleosome. The structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of each pair of four core histones (H2A, H2B, H3, and H4). By linking DNA interactions between histone H1 and nucleosomes, chromatin fibers are further compacted to form higher-order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts of this gene lack poly-A tails; instead, they contain a palindromic termination element. This gene is present in a histone cluster on chromosome 1. This gene is one of four duplicated histone genes in the cluster; this record represents the centromeric copy.