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Official Full Name: insulin like growth factor 2<br />Also known as: GRDF; SRS3; IGF-II; PP9974; C11orf43<br />This gene encodes a member of the insulin polypeptide growth factor family, involved in development and growth. It is an imprinted gene expressed exclusively from the paternal allele, and epigenetic alterations at this locus have been associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and silverrussell syndrome. There is a readable INS-igf2 gene whose 5' region overlaps with the INS gene and its 3' region overlaps with the INS gene. Alternative splice transcript variants of this gene have been found to encode distinct isoforms.