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CD366, also known as TIM-3, is a type I transmembrane glycoprotein belonging to the TIM family within the immunoglobulin superfamily. CD366 is expressed on Th1, Th17, Treg, NK, NK-T, dendritic cells, monocytes, mast cells and macrophages, but not on B cells and Th2 cells. CD366 regulates macrophage activation and is a negative regulator of Th1 cell function.