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Hemopexin (Hpx) is a single-chain polypeptide, an acute phase response protein synthesized by the liver. It has a specific binding ability to free heme. When extensive hemolysis occurs, plasma haptoglobin is depleted, and free hemoglobin in the circulation can be degraded into globin and heme. Heme is insoluble in water and can be combined with Hpx to form a complex and transported to the liver.