Analysis of Her3/ErbB3 by ELISA (CAT#: STEM-MB-1524-LGZ)

Introduction

Human epidermal growth factor receptor 3 (Her3), also known as ErbB3, is a type I transmembrane glycoprotein, a member of the ErbB family of tyrosine kinase receptors. ErbB3 binds to neuregulins NRG1 and NRG2, but lacks an effective kinase domain. Heterodimerization with another ErbB receptor is necessary for signal transduction. ErbB3 plays an important role in the development of Schwann cells, neural crest cells, heart valves and the sympathetic nervous system. Amplification of this gene and/or overexpression of its protein has been reported in many cancers, including prostate, bladder, and breast cancers. ErbB3 is highly expressed in a variety of tumors, and can cause tumor proliferation and drug resistance when activated. E3 ubiquitin ligase, monoclonal antibody and microRNA are the main molecular markers regulating the expression and function of ErbB3.