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Interleukin-31 (IL-31) is a protein encoded in humans by the IL31 gene located on chromosome 12. The biological role of IL-31 is still not fully understood. Studies have shown that IL-31 may play an important role in the induction of cytokines and chemokines in atopic dermatitis, pruritus, allergic asthma, cell proliferation and differentiation, hematopoietic, inflammatory response and immune response.