Analysis of PRLR by ELISA (CAT#: STEM-MB-1585-LGZ)

Introduction

The prolactin receptor (PRLR) is a cytokine receptor, encoded by a gene located on chromosome 5p13-14, that interacts with prolactin as a transmembrane receptor. PRLR includes an extracellular domain that binds prolactin, a transmembrane domain, and a cytoplasmic domain. PRLR is widely expressed in mammary gland, placenta, kidney, liver and pancreas, and it can be activated by growth hormone (GH) and human placental lactogen (hPL) in addition to prolactin. Studies have shown that the abnormality of PRLR is closely related to the pathogenesis and prognosis of certain tumors, especially breast cancer. The specific combination with PRLR can stimulate the growth of breast cancer cells, and some antagonists that can combine with PRLR but not form dimers can inhibit the growth of breast cancer cells. Several isoforms of PRLR exist, among which the soluble PRLR cannot transduce prolactin signaling.