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Official Full Name: isoleucyl-tRNA synthetase 1
Also known as: IRS; IARS; ILRS; ILERS; GRIDHH; PRO0785
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNAs by their cognate amino acids. Aminoacyl-tRNA synthetases are considered to be among the earliest proteins in evolution due to their central role in linking amino acids and nucleotide triplets contained in tRNAS. Isoleucine-tRNA synthetase belongs to the class I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. In addition, spliced transcript variants were found.