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Interleukin-18 (IL18, also known as interferon-γ-inducible factor) is a protein that in humans is encoded by the IL18 gene. The protein encoded by this gene is a pro-inflammatory cytokine. Many cell types, both hematopoietic and non-hematopoietic, have the potential to produce IL-18. Interleukin-18 (IL18, also known as interferon-γ-inducible factor) is a protein that in humans is encoded by the IL18 gene. The protein encoded by this gene is a pro-inflammatory cytokine. Many cell types, both hematopoietic and non-hematopoietic, have the potential to produce IL-18. IL-18 activity can be inhibited by bound extracellular interleukin-18-binding protein (IL-18BP).