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Interleukin-22 Receptor Subunit α-2 (IL22Rα2) belongs to the type ll cytokine receptor family. IL22Rα2 is a secreted protein and contains three fibronectin type-lll domains. IL22Rα2 is widely expressed in many tissues. IL22Rα2 functions as an IL22 antagonist and may be important in the regulation of inflammatory response. Three altemnatively spliced transcript variants encoding distinct isoforms have been described.