Analysis of IRAG1 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-2261-LGZ)

Introduction

Official Full Name: inositol 1,4,5-triphosphate receptor associated 1
Also known as: IRAG; JAW1L; MRVI1
The gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein is present in the endoplasmic reticulum membrane and is similar to Jaw1, a lymphocyte-restricted protein whose expression is downregulated during lymphocyte differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) and acts as a regulator of IP3-induced calcium release. Mouse studies have shown that the integration of MRV in Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation and thus may serve as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms of this gene have been identified and use alternative translation initiation sites, including non-aug (CUG) initiation sites.